Successful Treatment of Chronic Erythema Nodosum with Vitamin B12
Volkov,I., Rudoy, I., and Press, Y.J Am Board Fam Pract 2005;18:567–9.
Objectives: To present a case study of a patient successfully treated with Vitamin B12 for painful chronic erythema nodosum refractory to NSAIDs.
Methods: A 38 year old female vegetarian patient was diagnosed with chronic erythema nodosum, numbness in extremities and a sub-clinical deficiency of Vitamin B12. The patient was treated with biweekly intramuscular injections of 1000 mcg B12 for 4 weeks. This was followed by sublingual vitamin B12 (1000mcg, biweekly).
Results: The numbness and rash began to show clinical signs of improvement within 2 weeks of treatment initiation. No recurrence of symptoms were reported.
Conclusions: Physicians should check for subclinical deficiency of B12 in patients presenting with erythema nodosum or extremity numbness.